BETACELLULIN - A MITOGEN FROM PANCREATIC BETA-CELL TUMORS

被引：376

作者：

SHING, Y

CHRISTOFORI, G

HANAHAN, D

ONO, Y

SASADA, R

IGARASHI, K

FOLKMAN, J

机构：

[1] CHILDRENS HOSP MED CTR, DEPT SURG, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT BIOL CHEM, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA

[4] HARVARD UNIV, SCH MED, DEPT ANAT & CELLULAR BIOL, BOSTON, MA 02115 USA

[5] UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, HORMONE RES INST, SAN FRANCISCO, CA 94143 USA

[6] TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, OSAKA 532, JAPAN

来源：

SCIENCE | 1993年 / 259卷 / 5101期

关键词：

D O I：

10.1126/science.8456283

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

引用

页码：1604 / 1607

页数：4

共 30 条

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