NUCLEAR-ORGANIZATION - UNITING REPLICATION FOCI, CHROMATIN DOMAINS AND CHROMOSOME STRUCTURE

被引：42

作者：

JACKSON, DA

机构：

[1] CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, South Parks Road

来源：

BIOESSAYS | 1995年 / 17卷 / 07期

关键词：

D O I：

10.1002/bies.950170704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In higher eukaryotes, 'replication factories' coordinate DNA synthesis within local clusters of chromatin domains. Recent experiments((1,2)) have confirmed the complexity of these clusters and established that the organization of sites labelled during S phase persists throughout the cell cycle. This implies that domain clusters are critical elements of an hierarchy that is fundamental to both nuclear and chromosome structure.

引用

页码：587 / 591

页数：5

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