SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NEW NITRO-ALCOHOL DERIVATIVES

被引：33

作者：

MIKITE, G ^{[1
]}

JAKUCS, E ^{[1
]}

KISTAMAS, A ^{[1
]}

DARVAS, F ^{[1
]}

LOPATA, A ^{[1
]}

机构：

[1] CO COMP ASSISTED DRUG DESIGN, H-1502 BUDAPEST, HUNGARY

来源：

PESTICIDE SCIENCE | 1982年 / 13卷 / 05期

关键词：

D O I：

10.1002/ps.2780130515

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

New nitro-alcohol derivatives (36) were synthesized. Tested in vitro against Helminthosporium sativum, the compounds had high antifungal activities; the EC50 values varied between 10-2 and 10-6 M and, for the majority of the compounds, between 10-4 and 10-6 M. The EC50 values were calculated by probit anlaysis, except for the compounds with low activity, for which the values were estimated. Interesting relationships between the structure and antifungal action of the compounds were established.

引用

页码：557 / 562

页数：6

共 8 条

[1] BOCOBO FC, 1954, P SOC EXP BIOL MED, V85, P220, DOI 10.3181/00379727-85-20836
[2] BOCOBO FLORANTE C., 1956, ANTIBIOT AND CHEMOTHER, V6, P385
[3] ECKSTEIN Z, 1963, B ACAD POL SCI-CHIM, V11, P687
[4] ECKSTEIN Z, 1965, OESTERR CHEM ZTG, V66, P111
[5] Finney D.J., 1977, PROBIT ANAL, VIII
[6] A NEW SERIES OF ANTIFUNGAL COMPOUNDS
HODGE, EB
DAWKINS, JR
KROPP, E
[J]. JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION-SCIENTIFIC EDITION, 1954, 43 (08): : 501 - 502
[7] LEVAI L, 1979, Patent No. 4160035
[8] OSUMI J, 1972, Shikoku Acta Medica, V28, P245

← 1 →