ANALOGS OF TETRAHYDROFOLOC ACID 34 - HYDROPHOBIC BONDING TO DIHYDROFOLOC REDUCTASE .6. MODE OF PHENYL BINDING OF SOME 6-ARYLPYRIMIDINES

被引：42

作者：

BAKER, BR

SHAPIRO, HS

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1966年 / 55卷 / 03期

关键词：

D O I：

10.1002/jps.2600550309

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：308 / &

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[1] ANALOGS OF TETRAHYDROFOLIC ACID .7. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, AN INHIBITOR OF FOLIC REDUCTASE [J].

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[2] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES [J].

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JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) :24-&

[3] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

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JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[4] ANALOGS OF TETRAHYDROFOLIC ACID .24. FURTHER OBSERVATIONS ON MODE OF PYRIMIDYL BINDING TO DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE BY 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF INHIBITOR [J].

BAKER, BR ;

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JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (09) :1252-&

[5] ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES [J].

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SANTI, DV .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (10) :1415-&

[6]

BAKER BR, 1966, J PHARM SCI, V55, P295

[7] ANALOGS OF TETRAHYDROFOLIC ACID .26. SYNTHESIS OF SOME 5-ARYL AND 5-ARALKYL PYRIMIDINE-6-CARBOXYLIC ACIDS AND THEIR EFFECT ON DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (02) :162-&

[8] ANALOGS OF TETRAHYDROFOLIC ACID .30. INHIBITION OF DIHYDROFLOIC REDUCTASE BY SOME 6-SUBSTITUTED 2,4-DIAMINO-S-TRIAZINES [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :340-&

[9] ANALOGS OF TETRAHYDROFOLIC ACID .29. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .2. ON MODE OF PHENYL BINDING OF 1-ARYL-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINES [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :335-&

[10] ANALOGS OF TETRAHYDROFOLIC ACID .23. 1-(OMEGA-PHENYLALKYL)-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES AS INHIBITORS OF DIHYDROFOLIC REDUCTASE [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (01) :72-&

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