ANALYSIS OF THE IMMUNE-SYSTEM WITH TRANSGENIC MICE - T-CELL DEVELOPMENT

被引：6

作者：

BLUETHMANN, H

机构：

[1] Department PRTB, F. Hoffmann-La Roche Ltd, Basel

来源：

EXPERIENTIA | 1991年 / 47卷 / 09期

关键词：

TRANSGENIC MICE; IMMUNE SYSTEM; T-CELL DEVELOPMENT; T-CELL RECEPTOR; SCID MUTATION; LPR MUTATION;

D O I：

10.1007/BF01929878

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transgenic mice carrying functionally rearranged T cell receptor genes have contributed significantly to our knowledge of T cell development and thymic positive and negative selection processes. In addition, TCR-transgenic mice have been used to investigate mutations affecting thymocyte development, like scid and lpr. Gene targeting by homologous recombination will allow to analyze more specifically the molecular mechanisms underlying thymic selection and peripheral tolerance.

引用

收藏

页码：884 / 890

页数：7

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