HIGH PREVALENCE OF HYPERHOMOCYST(E)INEMIA IN PATIENTS WITH JUVENILE VENOUS THROMBOSIS

被引：235

作者：

FALCON, CR ^{[1
]}

CATTANEO, M ^{[1
]}

PANZERI, D ^{[1
]}

MARTINELLI, I ^{[1
]}

MANNUCCI, PM ^{[1
]}

机构：

[1] UNIV MILAN,MAGGIORE HOSP,IRCCS,INST INT MED,CTR ANGELO BIANCHI BONOMI HEMOPHILIA,MILAN,ITALY

来源：

ARTERIOSCLEROSIS AND THROMBOSIS | 1994年 / 14卷 / 07期

关键词：

HOMOCYSTEINE; VENOUS THROMBOSIS; PULMONARY EMBOLISM;

D O I：

10.1161/01.ATV.14.7.1080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We determined the prevalence of hyperhomocyst(e)inemia before and 4 hours after a methionine load (3.8 g/m(2)) in 80 patients (25 men and 55 women) who had had at least one verified episode of venous thromboembolism before the age of 40 years and in 51 healthy control subjects. No patient had any of the hemostatic abnormalities known to be associated with increased risk of venous thrombosis, and all had normal renal and liver function and no evidence of neoplastic disease. Hyperhomocyst(e)inemia was defined as fasting plasma homocyst(e)ine levels or absolute postload increments of homocyst(e)ine above the normal range. According to these diagnostic criteria, 15 patients (18.8%) and 1 control subject (1.9%) had hyperhomocyst(e)inemia. In 1 of these patients only, hyperhomocyst(e)inemia could be explained by low serum concentrations of vitamin B-12 and folates.

引用

页码：1080 / 1083

页数：4

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