THE COMPARISON OF EFFECTS OF VARIOUS ANESTHETICS ON EXPRESSION OF FOS PROTEIN IN THE RAT-BRAIN

被引：131

作者：

TAKAYAMA, K ^{[1
]}

SUZUKI, T ^{[1
]}

MIURA, M ^{[1
]}

机构：

[1] GUNMA UNIV,SCH MED,DEPT PHYSIOL,DIV 1,MAEBASHI,GUMMA 371,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

关键词：

C-FOS; ANESTHESIA; URETHANE; ALPHA-CHLORALOSE; PENTOBARBITAL SODIUM; HALOTHANE; FENTANYL; MIDAZOLAM;

D O I：

10.1016/0304-3940(94)90871-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to compare effects of various anesthetic drugs on expression of Fos protein in the supraspinal neurons of rats. Optimum anesthesia was maintained under monitoring of EEG. Degree of Fos expression was evaluated by counts of Fos-immunoreactive (ir) neurons. Urethane induced the largest amount of Fos-ir neurons (n = 8439), while fentanylimidazolam the smallest (n = 112), alpha-Chloralose, halothane, pentobarbital sodium and urethane/alpha-chloralose induced amounts in between. The results indicate that fentanyl/midazoIam is the most recommendable anesthetic drug in the Fos expression study.

引用

页码：59 / 62

页数：4

共 14 条

[1] EFFECTS OF SOME AUTONOMIC BLOCKING AGENTS ON HEART RATES OF ANAESTHETIZED AND PITHED RATS [J].

BARRETT, AM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1971, 15 (03) :267-+

[2] KINDLING STIMULATION INDUCES C-FOS PROTEIN(S) IN GRANULE CELLS OF THE RAT DENTATE GYRUS [J].

DRAGUNOW, M ;

ROBERTSON, HA .

NATURE, 1987, 329 (6138) :441-442

[3] THE USE OF C-FOS AS A METABOLIC MARKER IN NEURONAL PATHWAY TRACING [J].

DRAGUNOW, M ;

FAULL, R .

JOURNAL OF NEUROSCIENCE METHODS, 1989, 29 (03) :261-265

[4] A COMPARISON OF MEDIAN FREQUENCY, SPECTRAL EDGE FREQUENCY, A FREQUENCY BAND POWER RATIO, TOTAL POWER, AND DOMINANCE SHIFT IN THE DETERMINATION OF DEPTH OF ANESTHESIA [J].

DRUMMOND, JC ;

BRANN, CA ;

PERKINS, DE ;

WOLFE, DE .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1991, 35 (08) :693-699

[5] MIDAZOLAM AND FENTANYL-FLUANISONE - ASSESSMENT OF ANESTHETIC EFFECTS IN LABORATORY RODENTS AND RABBITS [J].

FLECKNELL, PA ;

MITCHELL, M .

LABORATORY ANIMALS, 1984, 18 (02) :143-146

[6]

KRUKOFF TL, 1992, J NEUROSCI, V12, P3582

[7]

MARSHALL BE, 1990, PHARMACOL BASIS THER, P285

[8]

MIURA M, IN PRESS J AUTON NER

[9] CHEMICALS AS TOOLS IN STUDY OF EXCITABLE MEMBRANES [J].

NARAHASHI, T .

PHYSIOLOGICAL REVIEWS, 1974, 54 (04) :813-889

[10]

Paxinos G., 1986, BRAIN NAVIGATOR, Vsecond

← 1 2 →