STANNYLATION IN THE ELECTROPHILIC 2-PYRIMIDINE AND 4/6-PYRIMIDINE POSITION AND THE USE OF STANNYLPYRIMIDINES IN COUPLING AND TIN-LITHIUM EXCHANGE-REACTIONS

被引：31

作者：

SANDOSHAM, J ^{[1
]}

UNDHEIM, K ^{[1
]}

机构：

[1] UNIV OSLO,DEPT CHEM,N-0315 OSLO,NORWAY

来源：

TETRAHEDRON | 1994年 / 50卷 / 01期

关键词：

D O I：

10.1016/S0040-4020(01)80750-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones were formed from the stannylpyrimidines and acid chlorides, aryl bromides required Pd-catalysis for coupling reaction.

引用

页码：275 / 284

页数：10

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