NERVE GROWTH-FACTOR REVERSES SPATIAL MEMORY IMPAIRMENTS IN AGED RATS

被引：23

作者：

FISCHER, W

机构：

[1] Department of Medical Cell Research, University of Lund, S-223 62 Lund

来源：

NEUROCHEMISTRY INTERNATIONAL | 1994年 / 25卷 / 01期

关键词：

D O I：

10.1016/0197-0186(94)90052-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aged rats, displaying impairments in spatial learning and memory associated with marked cellular atrophy of forebrain cholinergic neurons, received intracerebroventricular infusions of the neurotrophin nerve growth factor (NGF), or vehicle. During the 4-week infusion period rats receiving NGF showed improved acquisition and retention of spatial memory. With NGF this was accompanied by a significant reduction in cholinergic neuron atrophy in both septum, nucleus basalis and striatum. The cause of learning and memory deficits associated with ageing is not known. In the present paper we show that learning and memory deficits in aged rats can be reversed by NGF.

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页码：47 / 52

页数：6

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