LOCALIZED 2D J-RESOLVED H-1 MR SPECTROSCOPY - STRONG-COUPLING EFFECTS IN-VITRO AND IN-VIVO

被引：105

作者：

RYNER, LN ^{[1
]}

SORENSON, JA ^{[1
]}

THOMAS, MA ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,LOS ANGELES,CA 90095

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 06期

关键词：

2-DIMENSIONAL J-RESOLVED MR SPECTROSCOPY (2D J-PRESS); BRAIN PHANTOM; IN VIVO AND IN VITRO EFFECTS;

D O I：

10.1016/0730-725X(95)00031-B

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A two-dimensional (2D) J-resolved MR spectroscopy sequence (2D J-PRESS), fully localized in three dimensions, has been implemented on a whole-body MR scanner. A modified PRESS sequence with [90 degrees-180 degrees-t(1)/2-180 degrees-t(1)/2-acquisition] was used for voxel localization. An incremental delay (t(1)/2) was added to the intervals before and after the last slice-selective 180 degrees RF pulse to monitor the J-evolution in a localized 2D MR spectrum. Spectra were recorded with phantoms containing common cerebral metabolites-alanine, N-acetyl aspartate, glutamine, glutamate, taurine, myo-inositol, glucose, aspartate, GABA, and choline at 50 mM. In conformity with previously reported results, additional cross-peaks due to strong coupling were monitored in many metabolites. A brain phantom was developed to mimic the gray matter of human brain with the metabolites at physiological concentrations (0.5-12 mM). In vivo 2D J-PRESS spectra (n = 18) of healthy human brain were in conformity with those recorded from the brain phantom.

引用

页码：853 / 869

页数：17

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