SYNTHESIS OF NOVEL 2-SUBSTITUTED QUINOLINE DERIVATIVES - ANTIMICROBIAL, INOTROPIC, AND CHRONOTROPIC ACTIVITIES

Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3‐(13‐dioxolan‐2‐yl)‐2‐substituted thiocarbamoyl‐hydrazinoquinolines with different α‐halocarbonyl compounds. These series are: 3‐(1,3‐dioxolan‐2‐yl)‐2‐(3‐substituted‐4‐phenylthiazolin‐2‐ylidene)hy‐drazinoquinolines; 3‐(1,3‐dioxolan‐2‐yl)‐2‐(3‐substituted‐5‐ethoxycarbonyl‐4‐methylthiazoline‐2‐ylidene)hydrazinoquinolines and 3‐(1,3‐dioxolan‐2‐yl)‐2‐(3‐substituted‐4‐thiazolidinon‐2‐yl)hydrazinoquinolines. The active methylene group of the latter series was used for the preparation of their arylidene derivatives. The antimicrobial as well as inotropic and chronotropic activities of the prepared compounds were studied. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim