DISPARATE REACTIONS OF THIOESTERS OF (METHYLENECYCLOPROPYL)ACETIC AND BETA-(CYCLOPROPYLIDENE)PROPIONIC ACIDS WITH LITHIUM DIISOPROPYLAMIDE AND WITH GENERAL ACYL DEHYDROGENASE FROM PIG-KIDNEY

被引：6

作者：

BALDWIN, JE ^{[1
]}

GHATLIA, ND ^{[1
]}

PARKER, DW ^{[1
]}

机构：

[1] UNIV OREGON,DEPT CHEM,EUGENE,OR 97403

来源：

BIOORGANIC CHEMISTRY | 1990年 / 18卷 / 02期

关键词：

D O I：

10.1016/0045-2068(90)90044-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anion generated from the isopropyl thioester of (methylenecyclopropyl)acetic acid may be quenched with water to give an unrearranged thioester and an acyclic isomer, isopropyl 4-methylpenta-2E,4-dienethioate; the coenzyme A thioester of (methylenecyclopropyl)acetic acid is a known inactivator of acyl dehydrogenases. The isopropyl thioester of β-(cyclopropylidene) propionic acid reacts with LDA followed by water to give only 3-(cyclopropyl)prop-2E-enethioate, and its coenzyme A thioester does not inactivate the acyl dehydrogenase from pig kidney (EC 1.3.99.3). © 1990.

引用

页码：221 / 227

页数：7

共 15 条

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