RENAL EFFECTS OF CYCLOSPORINE

被引：30

作者：

BENNETT, WM ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV,DEPT PHARMACOL,PORTLAND,OR 97201

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1990年 / 23卷 / 06期

关键词：

D O I：

10.1016/0190-9622(90)70355-L

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Renal dysfunction is a frequent consequence of cyclosporine administration, even when cyclosporine blood concentrations are maintained within proper therapeutic levels. As dermatologie indications for this compound expand, it is important for clinicians to understand the relevant pharmacology and physiology that underlie cyclosporine-induced renal dysfunction. This article reviews the clinical pharmacology of cyclosporine, the principles of renal function testing, and the clinical manifestations of this drug's effects on the kidney. Sudden declines in kidney function, long-term cyclosporine nephrotoxicity, hemolytic-uremic syndrome, and hypertension are discussed from a clinical and experimental standpoint. Finally, practical suggestions are provided to aid the dermatologist in managing cyclosporine-treated patients. © 1990, American Academy of Dermatology, Inc.. All rights reserved.

引用

页码：1280 / 1287

页数：8

共 40 条

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