OPPOSITE EFFECTS OF NALTREXONE ON ETOH INTAKE BY SYRACUSE HIGH AND LOW AVOIDANCE RATS

被引：17

作者：

ISO, H ^{[1
]}

BRUSH, FR ^{[1
]}

机构：

[1] PURDUE UNIV, DEPT PSYCHOL SCI, W LAFAYETTE, IN 47907 USA

来源：

ALCOHOL | 1991年 / 8卷 / 06期

关键词：

SYRACUSE HIGH AND LOW AVOIDANCE RATS; BEHAVIORAL GENETICS; ETHANOL CONSUMPTION; ETHANOL PREFERENCE; NALTREXONE;

D O I：

10.1016/S0741-8329(91)90085-B

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Rats which were selectively bred for good (Syracuse High Avoidance: SHA) and poor (Syracuse Low Avoidance: SLA) shuttle-box avoidance learning were used to assess the effects of naltrexone on ethanol ingestion. Male rats from both strains were offered a free choice of water and ethanol (10%, v/v) for two 8-day periods between which was inserted a 4-day period of forced ethanol consumption. The net ethanol consumption and ethanol preference ratio were significantly greater in control SHA rats than in control SLA rats in the first choice period, but they did not differ in the forced and the second choice periods. Chronic naltrexone administration from an implanted 30-mg pellet showed bidirectional effects, i.e., suppression of ethanol consumption in SLA animals and enhancement in SHA rats.

引用

页码：443 / 448

页数：6

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