LINEAR SOLVATION ENERGY RELATIONSHIPS IN REVERSED-PHASE LIQUID-CHROMATOGRAPHY - EXAMINATION OF DELTABOND-C8 AS STATIONARY-PHASE FOR MEASURING LIPOPHILICITY PARAMETERS

被引：20

作者：

ALTOMARE, C ^{[1
]}

CELLAMARE, S ^{[1
]}

CAROTTI, A ^{[1
]}

FERAPPI, M ^{[1
]}

机构：

[1] UNIV BARI,DIPARTIMENTO FARMACOCHIM,VIA ORABONA 4,I-70125 BARI,ITALY

来源：

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1993年 / 12卷 / 03期

关键词：

LIPOPHILICITY; LINEAR SOLVATION ENERGY RELATIONSHIPS; REVERSED-PHASE LIQUID CHROMATOGRAPHY; SILANOL INTERACTIONS; HYDROGEN-BONDING;

D O I：

10.1002/qsar.19930120308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The lipophilicity of a large set of solutes was measured by reversed-phase high-performance liquid chromatography, using a novel stationary phase, namely Deltabond C-8 (DB), proposed to eliminate secondary adsorptive interactions. DB lipophilicity parameters have been found fairly well correlated with 1-octanol-water partition coefficients and a Linear Solvation Energy Relationship study has revealed that cavity term (modeled by intrinsic molar volume, V(I)) and hydrogen-bond acceptor capacity (modeled by the solvatochromic parameter beta) of solutes are the most important factors affecting retention on Deltabond C-8. Compared with other reversed phases, DB allowed to determine retention data with a significant time saving and yielded lipophilicity parameters less affected by interactions with silanols.

引用

页码：261 / 268

页数：8

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