THE IN-VITRO EFFECTS OF 3 LYSOSOMOTROPIC DETERGENTS AGAINST 3 HUMAN TUMOR-CELL LINES

被引：14

作者：

DUBOWCHIK, GM

GAWLAK, SL

FIRESTONE, RA

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492-7660

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/0960-894X(95)00136-H

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three lysosomotropic detergents, N-dodecylimidazole (NDI) 1, and two new analogues, serine dodecylamide (SDA) 2 and O-methyl serine dodecylamide (MSD) 3, were tested against three human tumor cell lines in vitro: HCT116, RCA and MCF-7. All three demonstrated dose-related cytotoxicity which, except for a few cases, was also dependent on incubation time, and visually resembled cell death by apoptosis.

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页码：893 / 898

页数：6

相关论文

共 19 条

[1] RATIONAL DELIVERY STRATEGIES FOR THE DESIGN OF PEPTIDES WITH ENHANCED ORAL DELIVERY [J].

BORCHARDT, RT .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, 20 (04) :469-483

[2] PH DEPENDENT CYTOTOXICITY OF N-DODECYLIMIDAZOLE - A COMPOUND THAT ACQUIRES DETERGENT PROPERTIES UNDER ACIDIC CONDITIONS [J].

BOYER, MJ ;

HORN, I ;

FIRESTONE, RA ;

STEELENORWOOD, D ;

TANNOCK, IF .

BRITISH JOURNAL OF CANCER, 1993, 67 (01) :81-87

[3] RELATIONSHIPS AMONG CYTOTOXICITY, LYSOSOMAL BREAKDOWN, CHROMOSOME-ABERRATIONS, AND DNA DOUBLE-STRAND BREAKS [J].

BRADLEY, MO ;

TAYLOR, VI ;

ARMSTRONG, MJ ;

GALLOWAY, SM .

MUTATION RESEARCH, 1987, 189 (01) :69-79

[4]

BUDAVARI S, 1989, MERCK INDEX, P8413

[5] EFFECTS OF LYSOSOMOTROPIC DETERGENTS ON THE HUMAN MALARIAL PARASITE PLASMODIUM-FALCIPARUM IN INVITRO CULTURE [J].

CABANTCHIK, ZI ;

SILFEN, J ;

FIRESTONE, RA ;

KRUGLIAK, M ;

NISSANI, E ;

GINSBURG, H .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (08) :1271-1277

[6]

DOUAY L, 1982, EXP HEMATOL, V10, P113

[7] LYSOSOMOTROPIC AGENTS .1. SYNTHESIS AND CYTOTOXIC ACTION OF LYSOSOMOTROPIC DETERGENTS [J].

FIRESTONE, RA ;

PISANO, JM ;

BONNEY, RJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (09) :1130-1133

[8] LYSOSOMOTROPIC AGENTS .7. BROAD-SPECTRUM ANTIFUNGAL ACTIVITY OF LYSOSOMOTROPIC DETERGENTS [J].

FIRESTONE, RA ;

PISANO, JM ;

GARRITY, GM ;

FROMTLING, RA ;

ZIMMERMAN, SB .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (08) :1519-1521

[9]

GORCZYCA W, 1992, INT J ONCOL, V1, P639

[10] KILLING OF SACCHAROMYCES-CEREVISIAE BY THE LYSOSOMOTROPIC DETERGENT N-DODECYLIMIDAZOLE [J].

HUSSAIN, M ;

LEIBOWITZ, MJ ;

LENARD, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (04) :512-517