Cell Signals Influencing Hepatic Fibrosis

被引：57

作者：

Cong, Min ^{[1
]}

Iwaisako, Keiko ^{[1
]}

Jiang, Chunyan ^{[1
]}

Kisseleva, Tatiana ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA

来源：

INTERNATIONAL JOURNAL OF HEPATOLOGY | 2012年 / 2012卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1155/2012/158547

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver fibrosis is the result of the entire organism responding to a chronic injury. Every cell type in the liver contributes to the fibrosis. This paper first discusses key intracellular signaling pathways that are induced during liver fibrosis. The paper then examines the effects of these signaling pathways on the major cell types in the liver. This will provide insights into the molecular pathophysiology of liver fibrosis and should identify therapeutic targets.

引用

页数：18

共 222 条

[1] Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state
Abraldes, JG
Iwakiri, Y
Loureiro-Silva, M
Haq, O
Sessa, WC
Groszmann, RJ
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (05): : G980 - G987
[2] Roles of STAT3 defined by tissue-specific gene targeting
Akira, S
[J]. ONCOGENE, 2000, 19 (21) : 2607 - 2611
[3] MOLECULAR-CLONING OF APRF, A NOVEL IFN-STIMULATED GENE FACTOR-3 P91-RELATED TRANSCRIPTION FACTOR INVOLVED IN THE GP130-MEDIATED SIGNALING PATHWAY
AKIRA, S
NISHIO, Y
INOUE, M
WANG, XJ
WEI, S
MATSUSAKA, T
YOSHIDA, K
SUDO, T
NARUTO, M
KISHIMOTO, T
[J]. CELL, 1994, 77 (01) : 63 - 71
[4] Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement
Albillos, A
de la Hera, A
González, M
Moya, JL
Calleja, JL
Monserrat, J
Ruiz-del-Arbol, L
Alvarez-Mon, M
[J]. HEPATOLOGY, 2003, 37 (01) : 208 - 217
[5] Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver
Alonzi, T
Maritano, D
Gorgoni, B
Rizzuto, G
Libert, C
Poli, V
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (05) : 1621 - 1632
[6] Toll-Like Receptor Signaling and Liver Fibrosis
Aoyama, Tomonori
Paik, Yong-Han
Seki, Ekihiro
[J]. GASTROENTEROLOGY RESEARCH AND PRACTICE, 2010, 2010
[7] CX3CL1-CX3CR1 Interaction Prevents Carbon Tetrachloride-Induced Liver Inflammation and Fibrosis in Mice
Aoyama, Tomonori
Inokuchi, Sayaka
Brenner, David A.
Seki, Ekihiro
[J]. HEPATOLOGY, 2010, 52 (04) : 1390 - 1400
[8] Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension
Arciniegas, Enrique
Frid, Maria G.
Douglas, Ivor S.
Stenmark, Kurt R.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2007, 293 (01) : L1 - L8
[9] Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
Arthur, HM
Ure, J
Smith, AJH
Renforth, G
Wilson, DI
Torsney, E
Charlton, R
Parums, DV
Jowett, T
Marchuk, DA
Burn, J
Diamond, AG
[J]. DEVELOPMENTAL BIOLOGY, 2000, 217 (01) : 42 - 53
[10] Mesenchymal Origin of Hepatic Stellate Cells, Submesothelial Cells, and Perivascular Mesenchymal Cells During Mouse Liver Development
Asahina, Kinji
Tsai, Shirley Y.
Li, Peng
Ishii, Mamoru
Maxson, Robert E., Jr.
Sucov, Henry M.
Tsukamoto, Hidekau
[J]. HEPATOLOGY, 2009, 49 (03) : 998 - 1011

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