VECURONIUM DOSE - RESPONSE AND MAINTENANCE REQUIREMENTS IN PATIENTS WITH MYASTHENIA-GRAVIS

被引：46

作者：

NILSSON, E ^{[1
]}

MERETOJA, OA ^{[1
]}

机构：

[1] UNIV HELSINKI,CENT HOSP,DEPT ANAESTHESIA,SF-00100 HELSINKI 10,FINLAND

来源：

ANESTHESIOLOGY | 1990年 / 73卷 / 01期

关键词：

: myasthenia gravis; Measurement technique: electromyography; mechanomyography; neuromuscular disease; neuromuscular relaxants: dose-response curves; vecuronium;

D O I：

10.1097/00000542-199007000-00005

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Eleven myasthenia gravis and seven control patients were studied during N2O/O2-fentanyl anesthesia to determine the ED50, ED95, and maintenance requirement of vecuronium using both mechanomyography and electromyography. The ED95 of vecuronium was 17 (range 8-34) μg/kg in patients with myasthenia gravis, and this was significantly related to patient's acetylcholine receptor antibody titer (r = -0.75, P < 0.01). The average ED95 value was 250% greater in control than in myasthenic patients (P < 0.01). The hourly requirement of vecuronium to maintain an 80-90% neuromuscular blockade was 38 ± 10 μg/kg in myasthenic and 120 ± 27 μg/kg in control patients (P < 0.001). When these requirements were related to individual ED95 doses, they were comparable indicating similar time durations of effect of vecuronium following an equipotent dose in myasthenic and in control patients.

引用

页码：28 / 32

页数：5

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