STEREOSPECIFIC COUPLING REACTION FOR INTERNUCLEOTIDE METHYL PHOSPHONOTHIOATE LINKAGE

被引：19

作者：

LEBEDEV, AV

RIFE, JP

SELIGSOHN, HW

WENZINGER, GR

WICKSTROM, E

机构：

[1] UNIV S FLORIDA,DEPT CHEM,TAMPA,FL 33620

[2] RUSSIAN ACAD SCI,INST BIOORGAN CHEM,NOVOSIBIRSK 630090,RUSSIA

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)94646-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The (Sp)- and (Rp)- diastereomers of 5′-dimethoxytritylthymidyl-(3′-5′)methylphosphono-5′-thio-3′-acetylthymidine were prepared by the stereospecific reaction of 5′-deoxy-5′-iodo-3′-acetylthymidine with the (Sp)- or (Rp)- diastereomers of 5′-dimethoxytritylthymidyl-3′methylphosphonothioate (Li+ salt) in DMF. At 50°C, the coupling reaction was complete within 6 hours. © 1990.

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页码：855 / 858

页数：4

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