CUTANEOUS METASTASES OF A GIANT-CELL TUMOR OF BONE - CASE-REPORT

被引:9
作者
CERRONI, L [1 ]
SOYER, HP [1 ]
SMOLLE, J [1 ]
KERL, H [1 ]
机构
[1] GRAZ UNIV,DEPT DERMATOL,AVENBRUGGERPL 8,A-8036 GRAZ,AUSTRIA
关键词
D O I
10.1111/j.1600-0560.1990.tb01679.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
A 47‐year‐old patient with the previous history of a giant cell tumor of the left femur presented with 3 cutaneous nodules located on the face. Histologic examination revealed skin metastases of a giant cell tumor of bone, with dermal and subcutaneous nodules characterized by multinucleate giant cells and mononuclear cells. The patient died 10 months later from widespread metastases to the lung and brain. A panel of enzymoand immunohistochemical markers reactive with osteoclastic, fibroblastic and histiocytic determinants was tested on the cutaneous lesions. The results indicated osteoclastic lineage of the multinucleate giant cells whereas the mononuclear cells showed features of fibroblastic differentiation. Cutaneous metastasis from a giant cell tumor of bone is an extraordinary event and so far has only been reported once. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码:59 / 63
页数:5
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