COLOR-VISION ANOMALIES FOLLOWING EXPERIMENTAL GLAUCOMA IN MONKEYS

被引：24

作者：

KALLONIATIS, M

HARWERTH, RS

SMITH, EL

DESANTIS, L

机构：

[1] College of Optometry, University of Houston, Houston, Texas

[2] Department of Optometry, University of Melbourne, Parkville

[3] Alcon Laboratories Incorporated, Fort Worth, Texas

来源：

OPHTHALMIC AND PHYSIOLOGICAL OPTICS | 1993年 / 13卷 / 01期

关键词：

D O I：

10.1111/j.1475-1313.1993.tb00427.x

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Spectral sensitivity defects, associated with chronic elevated intraocular pressure (IOP) produced by Argon laser trabeculoplasty, were studied in monkeys. Increment-threshold spectral sensitivity (ITSS) and threshold versus intensity (TVI) functions were measured using a behavioural model. Elevated IOP resulted in short wavelength (SW) sensitivity losses characteristic of many ocular diseases. The amount of SW sensitivity loss for ITSS functions depended upon the intensity level and chromatic composition of the background field. The optimum condition identifying the greatest SW sensitivity reduction was a yellow background of moderate intensity (100-1000 Td). In the early stages of experimental glaucoma, the cone mechanisms and the rod mechanism typically showed decreased test and field sensitivities. The SW cone pathway has slightly greater threshold elevation (almost-equal-to 0.3 log unit) compared to the rod and cone pathways. On the other hand, in the advanced stages of experimental glaucoma, the largest sensitivity losses were in the longer-wavelength, red-green opponent mechanism, with the rod and SW cone pathways showing smaller losses. The similarities of the colour vision anomalies in this animal model with those of patients with glaucoma, provides support for its use as an experimental model for human glaucoma.

引用

页码：56 / 67

页数：12

共 75 条

[1]

Vaughan D., Asbury T., General Ophthalmology, pp. 213-229, (1977)

[2]

Hitch R., Shields M.B., The Secondary Glaucomas, pp. 3-7, (1982)

[3]

Stiles W.S., Introductory essay–Increment thresholds in the analysis of colour‐sensitive mechanisms of vision: historical retrospect und comment on recent developments, Mechanisms of Colour Vision, Selected papers of W. S. Stiles, FRS with a new introductory essay, pp. 1-35, (1978)

[4]

Verriest G., Uvijls A., Spectral increment thresholds on a while background in different age groups of normal subjects and in acquired ocular diseases, Doc. Ophthalmol, 43, pp. 217-248, (1977)

[5]

King-Smith P.E., Rosten J.G., Alvarez S.L., Bhargava S.K., Human vision without tonic ganglion cells, Colour Vision Deficiencies V, pp. 99-105, (1980)

[6]

Adams A.J., Chromatic and luminosity processing in retinal disease, Am. J. Optom. Physiol. Opt., 59, pp. 954-960, (1982)

[7]

Adams A.J., Rodic R., Husted R., Stamper R., Spectral sensitivity and color discrimination changes in glaucoma and glaucoma‐suspect patients, Invest. Ophthalmol. Visual Sci, 23, pp. 516-524, (1982)

[8]

Adams A.J., Heron G., Husted R., Clinical measures of central vision function in glaucoma and ocular hypertension, Arch. Ophthalmol, 105, pp. 782-787, (1987)

[9]

Alvarez S.L., King-Smith P.E., Bhargava S.K., Luminance and colour dysfunction in retrobulbar neuritis, Colour Vision Efficiencies VI, pp. 441-443, (1982)

[10]

Alvarez S.L., King-Smith P.E., Bhargava S.K., Spectral threshold measurement and clinical applications, Br. J. Opthalmol, 67, pp. 504-507, (1983)

← 1 2 3 4 5 6 7 8 →