INVOLVEMENT OF SUBSTANCE-P AND EXCITATORY AMINO-ACIDS IN AVERSIVE BEHAVIOR ELICITED BY INTRATHECAL CAPSAICIN

被引：17

作者：

OKANO, K

KURAISHI, Y

SATOH, M

机构：

[1] KYOTO UNIV, FAC PHARMACEUT SCI, DEPT MOLEC PHARMACOL, KYOTO 60601, JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV, RES INST WAKAN YAKU, DEPT APPL BIOCHEM, TOYAMA, TOYAMA 93001, JAPAN

[3] KYOTO UNIV, DEPT PHARMACOL, KYOTO 60601, JAPAN

来源：

NEUROSCIENCE RESEARCH | 1994年 / 19卷 / 02期

关键词：

CAPSAICIN; EXCITATORY AMINO ACIDS; SUBSTANCE-P; AVERSIVE BEHAVIOR; INTRATHECAL; SPINAL CORD;

D O I：

10.1016/0168-0102(94)90135-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The rat given an intrathecal injection of capsaicin (0.3-10 nmol/rat) through a lumbar puncture showed biting or licking the tail and hind paws. The substance P antagonist, CP-96,345 (3 nmol/rat), co-administered intrathecally with capsaicin (10 nmol/rat), caused a significant inhibition of the behavioral responses to capsaicin (10 nmol/rat). When co-administered intrathecally with the NMDA antagonist, 2-amino-5-phosphonovaleric acid (APV, 10 nmol/rat), the capsaicin (10 nmol/rat) -induced behavioral responses were significantly inhibited. A co-administration of the non-NMDA antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 nmol/rat), resulted in a significant reduction of the behavioral responses produced by capsaicin (10 nmol/rat). Administration of the combination of two antagonists (CP-96,345 and either APV or CNQX, or APV and CNQX) more markedly inhibited the behavioral responses to capsaicin (10 nmol/rat) than when either antagonist was co-administered with capsaicin. The results suggest that aversive behaviors induced by intrathecal capsaicin are mediated not only by the activation of NK-1 receptors but also by that of NMDA and non-NMDA receptors.

引用

页码：125 / 130

页数：6

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