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ULTRAVIOLET LIGHT-INDUCED PATHOLOGY IN THE EYE - ASSOCIATED CHANGES IN OCULAR ALDEHYDE DEHYDROGENASE AND ALCOHOL-DEHYDROGENASE ACTIVITIES
被引：51
作者：
DOWNES, JE
[1
]
SWANN, PG
[1
]
HOLMES, RS
[1
]
机构：
[1] GRIFFITH UNIV,DIV SCI & TECHNOL,NATHAN,QLD 4111,AUSTRALIA
来源：
关键词：
UV LIGHT;
ALDEHYDE DEHYDROGENASE;
ALCOHOL DEHYDROGENASE;
MOUSE;
LENS;
D O I：
10.1097/00003226-199305000-00010
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Adult male C57BL/6J inbred mice were subjected to ultraviolet radiation (UVR) exposure (302-nm peak wavelength; average intensity 282 muW/cm2) for 1 h and monitored for ocular aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) activity changes over a period of 25 days. Dramatic reductions in activities were observed by 4-6 days postexposure, resulting in enzyme levels of 15-16% of control animals. Major decreases in corneal enzyme levels were predominantly responsible for these changes. Ocular morphology was observed throughout using a photoslit-lamp biomicroscope, with maximum corneal clouding occurring at days 4-6. These data support earlier proposals for major roles for these corneal enzymes in assisting the cornea in protecting the eye against UVR-induced tissue damage.
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页码：241 / 248
页数：8
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