STEEL FACTOR IS REQUIRED FOR MAINTENANCE, BUT NOT DIFFERENTIATION, OF MELANOCYTE PRECURSORS IN THE NEURAL CREST

被引：85

作者：

MURPHY, M ^{[1
]}

REID, K ^{[1
]}

WILLIAMS, DE ^{[1
]}

LYMAN, SD ^{[1
]}

BARTLETT, PF ^{[1
]}

机构：

[1] IMMUNEX RES & DEV CORP,SEATTLE,WA 98101

来源：

DEVELOPMENTAL BIOLOGY | 1992年 / 153卷 / 02期

关键词：

D O I：

10.1016/0012-1606(92)90124-Y

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skin melanocytes are derived from neural crest cells that migrate into the dermis during embryogenesis. Two mouse mutants, Steel and White dominant-spotting, which have defects in melanocyte production, have recently been shown to have deletions in the genes that code for a new growth factor, steel factor (SLF), and its receptor, respectively. Here, we have investigated the role that SLF plays in melanogenesis using cultures of mouse neural crest and found that its primary action is the maintenance of melanocyte precursors. It has no effect on the final stage of melanocyte differentiation, the production of melanin, which appears to require an additional factor whose action is mimicked by the phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate). © 1992.

引用

页码：396 / 401

页数：6

共 18 条

[1] REVERSAL OF A DEVELOPMENTAL RESTRICTION IN NEURAL CREST-DERIVED CELLS OF AVIAN EMBRYOS BY A PHORBOL ESTER DRUG [J].