ANTINEOPLASTIC AND ANTIVIRAL ACTIVITIES OF SOME CYCLOLIGNANS

被引：50

作者：

FELICIANO, AS ^{[1
]}

GORDALIZA, M ^{[1
]}

DELCORRAL, JMM ^{[1
]}

CASTRO, MA ^{[1
]}

GARCIAGRAVALOS, MD ^{[1
]}

RUIZLAZARO, P ^{[1
]}

机构：

[1] PHARMAMAR SA,E-28760 MADRID,SPAIN

来源：

PLANTA MEDICA | 1993年 / 59卷 / 03期

关键词：

JUNIPERUS-SABINA; CUPRESSACEAE; CYCLOLIGNANS; ANTINEOPLASTIC; P-388; A-549; HT-29; ANTIVIRAL; HSV-1; VSV;

D O I：

10.1055/s-2006-959660

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nineteen cyclolignans of varied structures, most of them isolated from Juniperus sabina leaves, were evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while the antiviral assays were performed on herpes simplex virus type 1 infecting fibroblasts of monkey kidney (HSV-1/CV-1) and on vesicular stomatitis virus infecting flbroblasts of hamster kidney (VSV/BHK). A number of substances were active in both types of assays at concentrations below 1 mug/ml; deoxypodophyllotoxin and beta-peltatin A methyl ether being the most potent compounds in all cases, with IC50 values in the range 2.5 - 4 ng/ml for the three neoplastic systems.

引用

页码：246 / 249

页数：4

共 13 条

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