LIMITING THE AVAILABLE T-CELL RECEPTOR REPERTOIRE MODIFIES ACUTE LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INDUCED IMMUNOPATHOLOGY

被引:12
作者
DOHERTY, PC [1 ]
HOU, S [1 ]
EVANS, CF [1 ]
WHITTON, JL [1 ]
OLDSTONE, MBA [1 ]
BLACKMAN, MA [1 ]
机构
[1] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA USA
关键词
IMMUNOPATHOLOGY; INFLAMMATION; CYTOTOXIC T LYMPHOCYTES; IMMUNODEFICIENCY;
D O I
10.1016/0165-5728(94)90076-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The invariably fatal immunopathological disease that follows intracerebral injection of CBA/Ca (H-2(k)) mice with 1000 PFU of lymphocytic choriomeningitis virus (LCMV) generally fails to develop in congenic mice transgenic for a V beta 8.1D beta 2J beta 2.3C beta 2 T cell receptor (TCR) gene. The majority of these LCMV-infected TCR-transgenic mice show a substantial meningitis of delayed onset, that resolves without causing any obvious clinical impairment. This inflammatory process depends on the involvement of V beta 8(+) T cells, but does not require the participation of the CD4(+) subset. The cytotoxic effecters that develop in both the transgenic mice and the CBA/Ca controls are lytic for target cells infected with a vaccinia construct expressing genes encoding the putative polymerase protein of LCMV. Limiting the available TCR repertoire to lymphocytes with a single V beta phenotype (not required for the generation of potent effecters in wild-type mice) thus modifies the development of the lethal neuropathology characteristic of LCMV infection, although the CD8(+) cytotoxic T lymphocyte response is not greatly compromised.
引用
收藏
页码:147 / 152
页数:6
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