EXTRACORPOREAL MEMBRANE-OXYGENATION WITH HEPARIN-COATED SYSTEMS IN A 13-MONTH-OLD INFANT WITH ACUTE HYPOXIC RESPIRATORY-FAILURE AFTER CORRECTION OF TETRALOGY OF FALLOT

被引：5

作者：

KEH, D

ROSSAINT, R

STREICH, R

GERLACH, H

PAPPERT, D

KRAMER, H

FALKE, KJ

机构：

[1] Department of Anesthesiology and Intensive Care Medicine, Rudolf Vlrchow Clinic, Free University of Berlin, Berlin, D-13353

[2] Department of Pediatric Cardiology, Christian-Albrechts-University, Kiel

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1995年 / 9卷 / 04期

关键词：

ACUTE RESPIRATORY FAILURE; EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO); HEPARIN-COATED SYSTEM; HEPARINIZATION;

D O I：

10.1016/S1010-7940(05)80153-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemorrhagic disorders due to systemic heparinization are frequent during extracorporeal lung support (veno-venous extracorporeal membrane oxygenation: vv-ECMO). The development of heparin-coated systems has reduced the need for high-dose heparinization. Whereas the use of these heparin-coated membrane lungs and tubings has been described in former studies in adults, only few reports exist in children. This case report describes the application of a heparin-coated extracorporeal system for long-term vv-ECMO in a 13-month-old infant suffering from acute hypoxic respiratory failure after correction of tetralogy of Fallot. Only moderately elevated levels of activated clotting time (ACT, 120-160 s) and activated partial thromboplastin time (aPTT, 40-60 s) were necessary to avoid thrombotic events in the extracorporeal system. Thoracotomies were performed twice without bleeding complications by discontinuation of the systemic heparinization. We conclude that the use of heparin-coated membrane lungs in infants may improve the safety of extracorporeal lung support and permits surgical intervention without major risk of bleeding.

引用

页码：226 / 229

页数：4

共 15 条

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