CAPILLARY GAS-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF N-BUTYL-P-AMINOBENZOATE AND LIDOCAINE IN PLASMA SAMPLES

被引：8

作者：

GROULS, RJE

MACHIELSEN, E

KORSTEN, HHM

HELLEBREKERS, LJ

BREIMER, DD

ACKERMAN, EW

机构：

[1] CATHARINA HOSP,DEPT ANESTHESIOL,5602 ZA EINDHOVEN,NETHERLANDS

[2] UNIV UTRECHT,FAC VET MED,DEPT CLIN SCI COMPAN ANIM,UTRECHT,NETHERLANDS

[3] UNIV UTRECHT,FAC VET MED,DEPT ANESTHESIOL,UTRECHT,NETHERLANDS

[4] CTR BIOPHARMACEUT SCI,LEIDEN,NETHERLANDS

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 673卷 / 01期

关键词：

D O I：

10.1016/0378-4347(95)00237-D

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A fast capillary gas chromatographic method with nitrogen-selective detection is described that allows selective and reproducible quantification of n-butyl-p-aminobenzoate (BAB) and lidocaine in plasma. The sampling and sample storage conditions are critical for the quantification of BAB. Diisopropyl fluorophosphate, an organophosphorus pesticide, has to be added during sampling to prevent the rapid decomposition of BAB by cholinesterases.

引用

页码：51 / 57

页数：7

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