BODY-MASS INDEX, WEIGHT-GAIN, AND RISK OF ENDOMETRIAL CANCER

被引:66
作者
OLSON, SH
TREVISAN, M
MARSHALL, JR
GRAHAM, S
ZIELEZNY, M
VENA, JE
HELLMANN, R
FREUDENHEIM, JL
机构
[1] Department of Social and Preventive Medicine State University of New York, Buffalo, NY
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1995年 / 23卷 / 02期
关键词
D O I
10.1080/01635589509514370
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Excess weight near the time of diagnosis is a well-established risk factor for endometrial cancer; less is known about the influence of weight at earlier periods of a woman's life or weight gain in adulthood. In a case-control study in western New York State, interviews were conducted with 232 incident endometrial cancer cases, diagnosed between 1986 and 1991, and 631 community controls. Body mass index at 16 years of age and 20, 10, and 2 years before interview and changes in body mass index between these time periods were examined While being relatively heavy at 16 years of age was associated with slightly increased risk [adjusted odds ratio (OR) = 1.28, 95% confidence interval (CI) = 0.84-1.96], large gains over the entire period from 16 years of age to 2 years ago (OR = 3.45, CI = 2.13-5.57) and high body mass index close to the time of diagnosis (OR = 3.21, CI = 2.01-5.15) were associated with greater risk. Differences in mean body mass index between cases and controls increased over time.
引用
收藏
页码:141 / 149
页数:9
相关论文
共 21 条
[1]   ASSOCIATION BETWEEN TEEN-AGE OBESITY AND CANCER IN 56,111 WOMEN - ALL CANCERS AND ENDOMETRIAL CARCINOMA [J].
BLITZER, PH ;
BLITZER, EC ;
RIMM, AA .
PREVENTIVE MEDICINE, 1976, 5 (01) :20-31
[2]   REPRODUCTIVE, MENSTRUAL, AND MEDICAL RISK-FACTORS FOR ENDOMETRIAL CANCER - RESULTS FROM A CASE-CONTROL STUDY [J].
BRINTON, LA ;
BERMAN, ML ;
MORTEL, R ;
TWIGGS, LB ;
BARRETT, RJ ;
WILBANKS, GD ;
LANNOM, L ;
HOOVER, RN .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 167 (05) :1317-1325
[3]   THE EPIDEMIOLOGY OF SERUM SEX-HORMONES IN POSTMENOPAUSAL WOMEN [J].
CAULEY, JA ;
GUTAI, JP ;
KULLER, LH ;
LEDONNE, D ;
POWELL, JG .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 129 (06) :1120-1131
[4]  
FALKNER KL, 1993, THESIS STATE U NEW Y
[5]  
HENDERSON BE, 1982, CANCER RES, V42, P3232
[6]   THE EPIDEMIOLOGY OF ENDOMETRIAL CANCER IN YOUNG-WOMEN [J].
HENDERSON, BE ;
CASAGRANDE, JT ;
PIKE, MC ;
MACK, T ;
ROSARIO, I ;
DUKE, A .
BRITISH JOURNAL OF CANCER, 1983, 47 (06) :749-756
[7]  
HENDERSON BE, 1988, CANCER RES, V48, P246
[8]   SERUM ANDROGENS AND ESTROGENS IN POST-MENOPAUSAL WOMEN WITH AND WITHOUT ENDOMETRIAL CANCER [J].
JUDD, HL ;
DAVIDSON, BJ ;
FRUMAR, AM ;
SHAMONKI, IM ;
LAGASSE, LD ;
BALLON, SC .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1980, 136 (07) :859-871
[9]   THE DOSE-EFFECT RELATIONSHIP BETWEEN UNOPPOSED ESTROGENS AND ENDOMETRIAL MITOTIC RATE - ITS CENTRAL ROLE IN EXPLAINING AND PREDICTING ENDOMETRIAL CANCER RISK [J].
KEY, TJA ;
PIKE, MC .
BRITISH JOURNAL OF CANCER, 1988, 57 (02) :205-212
[10]  
LAVECCHIA C, 1982, INT J EPIDEMIOL, V11, P120, DOI 10.1093/ije/11.2.120