RAPID EVALUATION OF TOPOISOMERASE INHIBITORS - CAFFEINE INHIBITION OF TOPOISOMERASES INVIVO

被引：43

作者：

SHIN, CG

STRAYER, JM

WANI, MA

SNAPKA, RM

机构：

[1] OHIO STATE UNIV,DEPT RADIOL,103 WISEMAN HALL,400 W 12TH AVE,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,COLUMBUS,OH 43210

来源：

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1990年 / 10卷 / 01期

关键词：

caffeine; camptothecin; ellipticine; m‐AMSA; topoisomerase I; topoisomerase II; topoisomerase poison; VM‐26; VP‐16;

D O I：

10.1002/tcm.1770100106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caffeine was found to inhibit both type I and type II topoisomerases in vivo as judged by its effects on replicating simian virus 40 (SV40) chromosomes. The study was facilitated by the use of a rapid filter assay for the detection and characterization of topoisomerase inhibitors. The assay, which requires neither purified enzymes nor substrates, was able to identify both antagonists and poisons of type I and type II topoisomerases. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：41 / 52

页数：12

共 36 条

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