INHIBITION OF NEURONAL 5-HT UPTAKE BY KETAMINE, BUT NOT HALOTHANE, INVOLVES DISRUPTION OF SUBSTRATE RECOGNITION BY THE TRANSPORTER

被引：41

作者：

MARTIN, DC ^{[1
]}

INTRONA, RP ^{[1
]}

ARONSTAM, RS ^{[1
]}

机构：

[1] MED COLL GEORGIA,DEPT PHARMACOL & TOXICOL,AUGUSTA,GA 30912

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 01期

关键词：

5-Hydroxytryptamine; Anesthetic; Brain; Halothane; Imipramine; Ketamine; Paroxetine; Serotonin; Serotonin receptor; Serotonin uptake;

D O I：

10.1016/0304-3940(90)90329-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of halothane and ketamine on (1) serotonin (5-hydroxytryptamine; 5-HT) uptake and (2) paroxetine binding to the 5-HT transporter in neuronal membranes were determined in rat brain. Both anesthetics inhibited the uptake of [3H]5-HT by synaptosomes, but only ketamine affected binding of [3H]paroxetine to the 5-HT transporter. Saturation analysis indicated that ketamine inhibition of [3H]paroxetine binding was competitive (Ki = 18.8 μM). These results indicate that halothane and ketamine inhibit 5-HT transport by different mechanisms. © 1990.

引用

页码：99 / 103

页数：5

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