QUINOLINATE PHOSPHORIBOSYL TRANSFERASE IS NOT THE OXYGEN-SENSITIVE SITE OF NICOTINAMIDE ADENINE-DINUCLEOTIDE BIOSYNTHESIS

被引:5
作者
GARDNER, PR [1 ]
FRIDOVICH, I [1 ]
机构
[1] DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
Free radicals; NAD[!sup]+[!/sup] biosynthesis-O[!sub]2[!/sub]-sensitive site; Oxygen toxicity; Quinolinate phosphoribosyl transferase;
D O I
10.1016/0891-5849(90)90083-U
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Quinolinate phosphoribosyl transferase (QPT)1 activity was not affected when Escherichia coli were treated with hyperbaric oxygen. This result is not in accord with a previous report (Biochem. Biophys. Res. Comm. 91:982-990; 1979) in which the enzyme was shown to be rapidly inactivated in E. Coli exposed to 4.2 atmospheres of oxygen. Our data rule out QPT as a site of oxygen toxicity and suggest other mechanisms for the inhibitory effects of hyperbaric oxygen on pyridine nucleotide biosynthesis. © 1990.
引用
收藏
页码:117 / 119
页数:3
相关论文
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