BIOADHESIVE ANALYSIS OF CONTROLLED-RELEASE SYSTEMS .4. AN EXPERIMENTAL-METHOD FOR TESTING THE ADHESION OF MICROPARTICLES WITH MUCUS

被引：45

作者：

MIKOS, AG ^{[1
]}

PEPPAS, NA ^{[1
]}

机构：

[1] PURDUE UNIV,SCH CHEM ENGN,W LAFAYETTE,IN 47907

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 12卷 / 01期

基金：

美国国家科学基金会;

关键词：

bioadhesion; colloidal particles; controlled release; flow channel method; microparticles;

D O I：

10.1016/0168-3659(90)90180-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new and simple method for testing and classifying the bioadhesive behavior of polymeric microparticles with or without drugs is presented. The method is used to determine the adhesive forces between solid polymeric microparticles of diameter up to 200 μm in contact with natural mucosa or with a mucin gel. A theoretical analysis is presented in order to calculate the adhesive characteristics of spherical microparticles in contact with mucus. © 1990.

引用

页码：31 / 37

页数：7

共 31 条

[1] Mikos, Peppas, Systems for controlled-release of drugs. V. Bioadhesive systems, S.T.P. Pharma, 2, pp. 705-716, (1986)
[2] Peppas, Buri, Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissue, J. Controlled Release, 2, pp. 257-275, (1985)
[3] Mikos, Peppas, Comparison of experimental techniques for the measurement of the bioadhesive forces of polymeric materials with soft tissues, Proc. Int. Symp. Controlled Release Bioact. Mater., 13, (1986)
[4] Robert, Buri, Peppas, Effect of degree of crosslinking on water transport in polymer microparticles, J. Controlled Release, 30, pp. 301-306, (1985)
[5] Barr-Howell, Peppas, Structural analysis of PHEMA microparticles, European Polymer Journal, 8, pp. 591-594, (1987)
[6] Robert, Buri, Peppas, Influence of the drug solibility and dissolution medium on the release from PHEMA microsphere, J. Controlled Release, 5, pp. 151-157, (1987)
[7] Mikos, Peppas, A model for prediction of the structural characteristics of EGDMA-cross-linked PHEMA microparticles during suspension copolymerization/crosslinking, J. Controlled Release, 5, pp. 53-62, (1987)
[8] Smart, Kellaway, Worthington, An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery, J. Pharm. Pharmacol., 36, pp. 295-305, (1984)
[9] Park, Robinson, Bioadhesive polymers as platforms for oral-controlled drug delivery: Method to study bioadhesion, Int. J. Pharm., 19, pp. 107-115, (1984)
[10] Ch'ng, Park, Kelly, Robinson, Bioadhesive polymers as platforms for oral controlled drug delivery. II. Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers, J. Pharm. Sci., 74, pp. 399-406, (1985)

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