EVALUATION OF VISCOUS OPHTHALMIC VEHICLES CONTAINING CARBOMER BY SLIT-LAMP FLUOROPHOTOMETRY IN HUMANS

被引：12

作者：

LUDWIG, A ^{[1
]}

UNLU, N ^{[1
]}

VANOOTEGHEM, M ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP,DEPT PHARMACEUT SCI,PHARMACEUT TOXICOL LAB,UNIV PL 1,B-2610 WILRIJK,BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 61卷 / 1-2期

关键词：

Carbomer; EDTA; Ocular retention; Precorneal kinetics; Slit-lamp fluorophotometry; Viscous eye drop;

D O I：

10.1016/0378-5173(90)90039-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Slit-lamp fluorophotometry was used to evaluate in humans the precorneal kinetics of viscous eye drops containing carbopol 940, disodium EDTA and a fluorescent tracer. The ocular retention of the tracer depends on the concentration of the polymer instilled. The addition of disodium EDTA does not improve the precorneal kinetics significantly. © 1990.

引用

页码：15 / 25

页数：11

共 31 条

[1] ENERGETIC STUDY OF THE GELATION OF CARBOPOL 940 [J].

ALAIN, M ;

BARDET, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1982, 12 (2-3) :173-183

[2]

BARDET L, 1978, ANN PHARM FR, V36, P323

[3]

BARDET L, 1975, ANN PHARM FR, V33, P651

[4]

BENEDETTO DA, 1975, INVEST OPHTH VISUAL, V14, P887

[5] ARTIFICIAL TEARS - EXPERIMENTAL AND CLINICAL OBSERVATIONS [J].

BREWITT, H .

KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 1988, 193 (03) :275-282

[6] PHARMACEUTICAL AND MEDICAL ASPECTS OF BIOADHESIVE SYSTEMS FOR DRUG ADMINISTRATION [J].

DUCHENE, D ;

TOUCHARD, F ;

PEPPAS, NA .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1988, 14 (2-3) :283-318

[7]

FRAUCH P, 1978, PHARM ACTA HELV, V53, P1

[8] MECHANISMS OF CORNEAL DRUG PENETRATION .2. ULTRASTRUCTURAL ANALYSIS OF POTENTIAL PATHWAYS FOR DRUG MOVEMENT [J].

GRASS, GM ;

ROBINSON, JR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (01) :15-23

[9]

GURNY R, 1987, OPHTHALMIC DRUG DELI, V11, P27

[10]

HARDBERGER R, 1975, ARCH OPHTHALMOL-CHIC, V93, P42

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