SR-89 CHLORIDE FOR PAIN PALLIATION IN PROSTATIC SKELETAL MALIGNANCY

被引:171
作者
LAING, AH
ACKERY, DM
BAYLY, RJ
BUCHANAN, RB
LEWINGTON, VJ
MCEWAN, AJB
MACLEOD, PM
ZIVANOVIC, MA
机构
[1] ROYAL S HANS HOSP,DEPT RADIOTHERAPY,SOUTHAMPTON SO9 4PE,HANTS,ENGLAND
[2] SOUTHAMPTON GEN HOSP,DEPT NUCL MED,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND
[3] CROSS CANC INST,DEPT NUCL MED,EDMONTON T6G 1Z2,ALBERTA,CANADA
[4] AMERSHAM INT PLC,AMERSHAM HP7 9LL,BUCKS,ENGLAND
[5] FREEDOM FIELDS HOSP,DEPT RADIOTHERAPY,PLYMOUTH PL4 7JJ,ENGLAND
关键词
SR-89; PROSTATE; BONE PAIN TREATMENT;
D O I
10.1259/0007-1285-64-765-816
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In a multi-centre study strontium-89 was shown to be effective in relieving bone pain from prostatic carcinoma in patients who had failed conventional therapies. Of 83 patients assessed at 3 months, following the administration of a dose of at least 1.5 MBq/kg, 75% derived benefit and 22% became pain free. Symptomatic improvement usually occurred within 6 weeks and continued for between 4 and 15 months (mean 6 months). Based on the dose estimation part of this study the recommended dose of strontium-89 is 150 MBq. Toxicity was low, provided platelet levels were above 100 x 10(9) l-1 at the time of treatment. Repeat treatments with strontium-89 may be given at intervals of not less than 3 months. Strontium-89 is administered intravenously on an out-patient basis with no special radiological protection precautions.
引用
收藏
页码:816 / 822
页数:7
相关论文
共 38 条
[1]  
ALLEN KL, 1976, CANCER, V37, P984, DOI 10.1002/1097-0142(197602)37:2<984::AID-CNCR2820370255>3.0.CO
[2]  
2-C
[3]  
BLAKE GM, 1989, EUR J NUCL MED, V15, P49
[4]  
BLAKE GM, 1988, J NUCL MED, V29, P549
[5]   SR-89 THERAPY - STRONTIUM KINETICS IN DISSEMINATED CARCINOMA OF THE PROSTATE [J].
BLAKE, GM ;
ZIVANOVIC, MA ;
MCEWAN, AJ ;
ACKERY, DM .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1986, 12 (09) :447-454
[6]  
BUCHALI K, 1988, EUR J NUCL MED, V14, P349
[7]  
Burnet N G, 1990, Clin Oncol (R Coll Radiol), V2, P220, DOI 10.1016/S0936-6555(05)80172-4
[8]  
COOPER JR, 1989, NRPM193 NAT RAD PROT
[9]  
CORWIN L A JR, 1988, Journal of Nuclear Medicine, V29, P903
[10]  
DEBRUYNE FMJ, 1988, MANAGEMENT ADV CANCE, P27