A HYBRID OF AMPHIPHILIC ALPHA-HELICAL PEPTIDES AND MESO-TETRA(ALPHA,ALPHA,ALPHA,ALPHA-ORTHO-CARBOXYPHENYL)-PORPHYRIN - MEMBRANE-PENETRATING PORPHYRIN-4-ALPHA-HELIX ARTIFICIAL PROTEIN

被引：38

作者：

MIHARA, H ^{[1
]}

NISHINO, N ^{[1
]}

HASEGAWA, R ^{[1
]}

FUJIMOTO, T ^{[1
]}

机构：

[1] KYUSHU INST TECHNOL, FAC ENGLISH, DEPT APPL CHEM, KITAKYUSHU 804, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 09期

关键词：

D O I：

10.1246/cl.1992.1805

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four amphiphilic alpha-helical peptides were hybridized with alpha,alpha,alpha,alpha-isomer of meso-tetra(o-carboxyphenyl)porphyrin to synthesize a picket-fence-type 4alpha-helix bundle polypeptide. The peptide sequence was designed so that the hybrid polypeptide could penetrate into phospholipid bilayers. Circular dichroism spectra showed that the hybrid folds in a complete four alpha-helix bundle structure both in methanol and dipalmitoylphosphatidylcholine vesicles.

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页码：1805 / 1808

页数：4

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