2 YEARS EXPERIENCE WITH 2 RECOMBINANT FACTOR-VIII CONCENTRATES

被引：7

作者：

BRACKMANN, HH ^{[1
]}

AYGOREN, E ^{[1
]}

SCHARRER, I ^{[1
]}

SCHWAAB, R ^{[1
]}

HAMMERSTEIN, U ^{[1
]}

OLDENBURG, J ^{[1
]}

机构：

[1] UNIV FRANKFURT,CTR INTERNAL MED,W-6000 FRANKFURT,GERMANY

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 1993年 / 4卷 / 03期

关键词：

HEMOPHILIA-A; RECOMBINANT FACTOR-VIII CONCENTRATES; CLINICAL EXPERIENCE;

D O I：

10.1097/00001721-199306000-00004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transmission of infectious diseases via the use of plasma concentrates has lent special significance to the manufacture of recombinant coagulation factor concentrates. At present, two factor VIII concentrates manufactured by recombinant DNA technology, produced by Baxter (Recombinate(TM)) and Bayer/Miles (Kogenate(TM)), are undergoing clinical trials. At the haemophilia centres in Bonn and Frankfurt am Main a total of 4.1 million IU have been used by twelve patients for prophylaxis and treatment for bleeding between 1989 and 1990. The clinical efficacy, particularly in the treatment of bleeding episodes was good and corresponded with that of plasma-derived concentrates. There were no allergic reactions, development of inhibitors or other serious side effects. In laboratory investigations no adverse results were encountered.

引用

页码：421 / 424

页数：4

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