THE IMMUNODOMINANT PEPTIDE FROM LISTERIOLYSIN IN QUIL-A LIPOSOMES VACCINATES CD8+ CYTOLYTIC T-CELLS AND CONFERS PROTECTION TO INFECTION

Cytolytic T-cell vaccination with immunodominant MHC class I-restricted peptides contained within Quil A liposomes has been previously demonstrated. In recent years, Quil A has been under consideration for use as an adjuvant in humans. We assessed the possible use of peptide inoculation in the context of Quil A liposomes to be protective in a mouse model. Listeria monocytogenes was used as the challenge pathogen and the previously identified listeriolysin 91-99 peptide as the immunogen, The listeriolysin 91-99 Quil A liposome inoculum showed significant enhancement of survival after challenge with up to 10 times the L. monocytogenes LP(50).