TRANSVERSE LIMB DEFICIENCY, FACIAL CLEFTING AND HYPOXIC RENAL DAMAGE - AN ASSOCIATION WITH TREATMENT OF MATERNAL HYPERTENSION

被引：15

作者：

HURST, JA

HOULSTON, RS

ROBERTS, A

GOULD, SJ

TINGEY, WG

机构：

[1] OXFORD RADCLIFFE TRUST,OXFORD REG GENET SERV,OXFORD OX3 7LJ,ENGLAND

[2] SOUTHAMPTON GEN HOSP,DEPT CLIN GENET,DIV CHILD HLTH,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND

[3] JOHN RADCLIFFE HOSP,OXFORD RADCLIFFE TRUST,DEPT PATHOL,OXFORD OX3 9DU,ENGLAND

[4] WYCOMBE GEN HOSP,DEPT OBSTET,HIGH WYCOMBE HP11 2TT,BUCKS,ENGLAND

来源：

CLINICAL DYSMORPHOLOGY | 1995年 / 4卷 / 04期

关键词：

TRANSVERSE LIMB DEFECTS; HYPERTENSIVE THERAPY; PRAZOSIN; LABETALOL;

D O I：

10.1097/00019605-199510000-00013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood now, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events.

引用

页码：359 / 363

页数：5

共 8 条

[1]

Bourget P., 1993, Journal de Gynecologie Obstetrique et Biologie de la Reproduction, V22, P871

[2] IDENTICAL PHALANGEAL DEFECTS INDUCED BY PHENYTOIN AND NIFEDIPINE SUGGEST FETAL HYPOXIA AND VASCULAR DISRUPTION BEHIND PHENYTOIN TERATOGENICITY [J].