SYNTHESIS, STRUCTURE ELUCIDATION AND BIOLOGICAL EVALUATION OF C-NORPACLITAXEL

被引：11

作者：

LIANG, X ^{[1
]}

KINGSTON, DGI ^{[1
]}

LONG, BH ^{[1
]}

FAIRCHILD, CA ^{[1
]}

JOHNSTON, KA ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 43期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01650-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of 2'-TBDMS-6 alpha-hydroxy-7-epipaclitaxel (1) with lead tetraacetate furnished 2'-TBDMS-C-norpaclitaxel (2) and the C-seco compound 3. Deprotection of 2 with pyridinium hydrofluoride yielded C-norpaclitaxel (4). C-norpaclitaxel (4) is less effective at promoting the assembly of microtubules and less cytotoxic towards HCT116 cells than paclitaxel.

引用

页码：7795 / 7798

页数：4

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