AMMONIA INDUCED DECREASE IN GLIAL FIBRILLARY ACIDIC PROTEIN IN CULTURED ASTROCYTES

被引：76

作者：

NORENBERG, MD

NEARY, JT

NORENBERG, LOB

MCCARTHY, M

机构：

[1] VET ADM MED CTR,NEUROPATHOL LAB,MIAMI,FL 33125

[2] VET ADM MED CTR,DEPT PATHOL,MIAMI,FL 33125

[3] VET ADM MED CTR,DEPT NEUROL,MIAMI,FL 33125

[4] UNIV MIAMI,JACKSON MEM HOSP,MIAMI,FL 33136

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 1990年 / 49卷 / 04期

关键词：

Ammonia; Astrocytes; Encephalopathy; Epatic; Glial fibrillary acidic protein;

D O I：

10.1097/00005072-199007000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous studies of human hepatic encephalopathy (HE) have shown decreased levels of glial fibrillary acidic protein (GFAP) in Alzheimer type II astrocytes. In view of the important role of ammonia in the pathogenesis of HE, we carried out immunocytochemical and enzyme-linked immunosorbent assay (ELISA) studies on the effect of ammonium chloride (10 mM) on GFAP content in primary astrocyte cultures. There was a 39% loss of GFAP after a four day treatment. There was no fall in total cell protein. Potential mechanisms for this apparent selective loss of GFAP are discussed. © 1990 by the American Association of Neuropathologists.

引用

页码：399 / 405

页数：7

共 40 条

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