CELLULAR-DISTRIBUTION OF OMEGA-3 (PERIPHERAL TYPE BENZODIAZEPINE) BINDING-SITES IN THE NORMAL AND ISCHEMIC RAT-BRAIN - AN AUTORADIOGRAPHIC STUDY WITH THE PHOTOAFFINITY LIGAND [H-3] PK-14105

被引：33

作者：

BENAVIDES, J ^{[1
]}

DUBOIS, A ^{[1
]}

GOTTI, B ^{[1
]}

BOURDIOL, F ^{[1
]}

SCATTON, B ^{[1
]}

机构：

[1] SYNTHELABO LERS,ETUD & RECH SCI LAB,DEPT BIOL,31 AVE PAUL VAILLANT COUTURIER,F-92220 BAGNEUX,FRANCE

来源：

NEUROSCIENCE LETTERS | 1990年 / 114卷 / 01期

关键词：

Astrocytes; Ischaemic; Macrophages; Photoaffinity labelling; Rat brain; [!sub]3[!/sub]H]PK 14105; ω[!sub]3[!/sub] (Peripheral type benzodiazepine) binding sites;

D O I：

10.1016/0304-3940(90)90424-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The microscopic distribution of ω3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of ω3 sites were present in the ependymal cells, the apical pole of the secretory cells in the choroid plexus and astrocyte-like cells in the outer cellular layer of the olfactory bulb. In ischaemic brain lesions caused by middle cerebral artery occlusion in spontaneously hypertensive rats or in spontaneous ischaemic and haemorrhagic lesions in spontaneously hypertensive stroke-prone rats, the proliferating ω3 sites were associated with reactive glial cells and macrophages. © 1990.

引用

页码：32 / 38

页数：7

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