EFFECTS OF HUMIC ACIDS, PARA-AMINOBENZOIC ACID AND ASCORBIC-ACID ON THE N-NITROSATION OF THE CARBAMATE INSECTICIDE PROPOXUR AND ON THE MUTAGENICITY OF NITROSOPROPOXUR

被引：18

作者：

GICHNER, T ^{[1
]}

BADAEV, SA ^{[1
]}

POSPISIL, F ^{[1
]}

VELEMINSKY, J ^{[1
]}

机构：

[1] MOSCOW CHEM PHYS INST, MOSCOW, USSR

来源：

MUTATION RESEARCH | 1990年 / 229卷 / 01期

关键词：

Antimutagenic effects; Arabidopis thaliana; Ascorbic acid; Humic acids; Nitrosated propoxur; para-Aminobenzoic acid;

D O I：

10.1016/0027-5107(90)90006-P

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nitrosation of the carbamate insecticide propoxur at pH 3 and 37°C was determined colorimetrically and found to be time- and sodium nitrite concentration-dependent. Nitrosated propoxur was mutagenic when exposed to the seeds of the higher plant Arabidopsis thaliana but the formation of nitrosopropoxur, the presumed mutagen, was inhibited by humic acids, para-aminobenzoic acid and ascorbic acid. These agents also reduced the mutagenicity of performed nitrosopropoxur. © 1990.

引用

收藏

页码：37 / 41

页数：5

相关论文

共 26 条

[1] HUMIC ACIDS INHIBIT THE FORMATION BUT NOT THE MUTAGENICITY OF N-METHYL-N-NITROSOUREA [J].

BADAEV, SA ;

GICHNER, T ;

POSPISIL, F ;

VELEMINSKY, J .

MUTATION RESEARCH, 1989, 210 (01) :9-13

[2]

BLEVINS RD, 1977, MUTAT RES, V44, P1

[3] MECHANISM OF INHIBITION OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE-INDUCED MUTAGENESIS BY PHENOLIC-COMPOUNDS [J].

CHAN, RIM ;

SAN, RHC ;

STICH, HF .

CANCER LETTERS, 1986, 31 (01) :27-34

[4] INHIBITION OF N-METHYL-N-NITROSOUREA-INDUCED MUTAGENICITY AND DNA METHYLATION BY ELLAGIC ACID [J].

DIXIT, R ;

GOLD, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8039-8043

[5]

ELESPURU RK, 1973, FOOD COSMET TOXICOL, V11, P807, DOI 10.1016/0015-6264(73)90139-9

[6] SPECTROPHOTOMETRIC DETERMINATION OF STREPTOZOTOCIN [J].

FORIST, AA .

ANALYTICAL CHEMISTRY, 1964, 36 (07) :1338-&

[7] ANTIMUTAGENIC EFFECT OF PARA-AMINOBENZOIC ACID ON THE MUTAGENICITY OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE IN SALMONELLA-TYPHIMURIUM [J].

GICHNER, T ;

VELEMINSKY, J ;

RAPOPORT, IA ;

VASILIEVA, SV .

MUTATION RESEARCH, 1987, 192 (02) :95-98

[8] 2 TYPES OF ANTIMUTAGENIC EFFECTS OF GALLIC AND TANNIC ACIDS TOWARDS N-NITROSO-COMPOUNDS-INDUCED MUTAGENICITY IN THE AMES SALMONELLA ASSAY [J].

GICHNER, T ;

POSPISIL, F ;

VELEMINSKY, J ;

VOLKEOVA, V ;

VOLKE, J .

FOLIA MICROBIOLOGICA, 1987, 32 (01) :55-62

[9] MECHANISMS OF INHIBITION OF N-NITROSO COMPOUNDS-INDUCED MUTAGENICITY [J].

GICHNER, T ;

VELEMINSKY, J .

MUTATION RESEARCH, 1988, 202 (02) :325-334

[10] INHIBITORY EFFECTS OF PARA-AMINOBENZOIC ACID ON THE FORMATION AND MUTAGENICITY OF N-NITROSO COMPOUNDS [J].

GICHNER, T ;

VELEMINSKY, J .

MUTAGENESIS, 1988, 3 (04) :329-331