AN IMMUNOPOTENTIATOR OF BETA-1,6,1,3 D-GLUCAN PREVENTS DIABETES AND INSULITIS IN BB RATS

被引：9

作者：

KIDA, K ^{[1
]}

INOUE, T ^{[1
]}

KAINO, Y ^{[1
]}

GOTO, Y ^{[1
]}

IKEUCHI, M ^{[1
]}

ITO, T ^{[1
]}

MATSUDA, H ^{[1
]}

ELLIOTT, RB ^{[1
]}

机构：

[1] UNIV AUCKLAND,SCH MED,DEPT PEDIAT,AUCKLAND,NEW ZEALAND

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1992年 / 17卷 / 02期

关键词：

BB RAT; BETA-1,6,1,3 D-GLUCAN; INSULITIS; LYMPHOCYTES-T SUBSET; IMMUNOTHERAPY;

D O I：

10.1016/0168-8227(92)90152-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The preventive effect of an immunopotentiator, beta-1,6;1,3 D-glucan, on the development of diabetes and insulitis was studied in BB rats. The intravenous administration of 1 mg kg-1 week-1 of beta-1,6;1,3 D-glucan from the age of 4 weeks decreased the cumulative incidence of diabetes from 43.3 % (13/30) to 6.7% (2/30) (P<0.005) and also the incidence of insulitis from 82.4% (14/17) to 26.3% (5/19) at the age of 20 weeks (P<0.002). Eight of nine rats were free from diabetes for 5 weeks after stopping beta-1,6;1,3 D-glucan at the age of 20 weeks. The total numbers of leukocytes in the peripheral blood and spleen of the rats were increased by beta-1,6;1,3 D-glucan treatment (P<0.05), whereas their T lymphocytes subsets were not changed. These data indicate that immunopotentiators could modulate the autoimmune mechanisms directed to pancreatic islets and inhibit the development of diabetes in BB rats.

引用

页码：75 / 79

页数：5

共 19 条

[1] PREVENTION OF DIABETES IN BB/WOR RAT BY SINGLE TRANSFUSION OF SPLEEN-CELLS - PARAMETERS THAT AFFECT DEGREE OF PROTECTION [J].