CHANGES IN SERUM SEX STEROID-LEVELS DURING MEGESTROL-ACETATE THERAPY

被引：5

作者：

POMMIER, RF

WOLTERING, EA

FLETCHER, WS

机构：

[1] Department of Surgery, Section of Surgical Oncology, Oregon Health Sciences University, Portland, OR

来源：

SURGICAL ONCOLOGY-OXFORD | 1994年 / 3卷 / 06期

关键词：

BREAST NEOPLASMS; HORMONE THERAPY; MEGESTROL ACETATE; NEUROENDOCRINE AXIS; RADIOIMMUNOASSAY; SEX STEROIDS;

D O I：

10.1016/0960-7404(94)90074-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We hypothesized that megestrol acetate (MA) may work on breast carcinoma by inducing changes in serum sex steroid levels. We prospectively measured levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone (DHEA), estrone (E(1)), and estradiol (E(2)) in 18 postmenopausal women before and during megestrol acetate therapy. MA significantly suppressed serum FSH, LH, DHEA and E(1) levels. However, this was accompanied by a marked increase in serum E(2) levels as measured by radioimmunoassay performed on whole serum. MA did not cross-react with the anti-E(2) antibodies used in the assay. Elevated E(2) levels also occurred in oophorectomized and/or adrenalectomized patients indicating the ovary and adrenal are not the source of the elevated E(2) levels. We conclude that MA may be metabolized to oestrogenic compounds that crossreact with antibodies to E(2), explaining the elevated E(2) levels observed. The effects of these oestrogenic metabolites on breast carcinoma are unknown.

引用

页码：351 / 359

页数：9

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