ENVIRONMENTALLY COMPATIBLE SYNTHESIS OF CATECHOL FROM D-GLUCOSE

被引：52

作者：

DRATHS, KM ^{[1
]}

FROST, JW ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV, DEPT CHEM, E LANSING, MI 48824 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 117卷 / 09期

关键词：

D O I：

10.1021/ja00114a003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biocatalytic alternative to currently employed industrial synthesis of catechol has been developed. Klebsiella pneumoniae genes encoding 3-dehydroshikimate dehydratase (aroZ) and protocatechuic acid decarboxylase (aroY) were introduced into an Escherichia coli construct that synthesizes elevated levels of 3-dehydroshikimic acid. One of the resulting biocatalysts, E. coli AB2834/pKD136/pKD9.069A, synthesizes 18.5 +/- 2.0 mM catechol from 56 mM D-glucose on 1 L scale.

引用

页码：2395 / 2400

页数：6

共 58 条

[1] [Anonymous], 1993, SHIKIMIC ACID METABO
[2] AUSUBEL FM, 1987, CURRENT PROTOCOLS BI
[3] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4] IDENTIFICATION AND REMOVAL OF IMPEDIMENTS TO BIOCATALYTIC SYNTHESIS OF AROMATICS FROM D-GLUCOSE - RATE-LIMITING ENZYMES IN THE COMMON PATHWAY OF AROMATIC AMINO-ACID BIOSYNTHESIS
DELL, KA
FROST, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (24) : 11581 - 11589
[5] PROTOCATECHUATE IS NOT METABOLIZED VIA CATECHOL IN ENTEROBACTER-AEROGENES
DOTEN, RC
ORNSTON, LN
[J]. JOURNAL OF BACTERIOLOGY, 1987, 169 (12) : 5827 - 5830
[6] GENOMIC DIRECTION OF SYNTHESIS DURING PLASMID-BASED BIOCATALYSIS
DRATHS, KM
FROST, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (26) : 9630 - 9632
[7] CONVERSION OF D-GLUCOSE INTO CATECHOL - THE NOT-SO-COMMON PATHWAY OF AROMATIC BIOSYNTHESIS
DRATHS, KM
FROST, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (24) : 9361 - 9363
[8] BIOCATALYSIS AND 19TH-CENTURY ORGANIC-CHEMISTRY - CONVERSION OF D-GLUCOSE INTO QUINOID ORGANICS
DRATHS, KM
WARD, TL
FROST, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (24) : 9725 - 9726
[9] SYNTHESIS USING PLASMID-BASED BIOCATALYSIS - PLASMID ASSEMBLY AND 3-DEOXY-D-ARABINO-HEPTULOSONATE PRODUCTION
DRATHS, KM
FROST, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (04) : 1657 - 1659
[10] BIOCATALYTIC SYNTHESIS OF AROMATICS FROM D-GLUCOSE - THE ROLE OF TRANSKETOLASE
DRATHS, KM
POMPLIANO, DL
CONLEY, DL
FROST, JW
BERRY, A
DISBROW, GL
STAVERSKY, RJ
LIEVENSE, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (10) : 3956 - 3962

← 1 2 3 4 5 6 →