CHEMICALLY-MODIFIED POLYSACCHARIDES FOR ENZYMATICALLY-CONTROLLED ORAL-DRUG DELIVERY

被引：44

作者：

KOST, J

SHEFER, S

机构：

[1] Department of Chemical Engineering, Ben-Guhon University of the Negev, Beer-Sheva

来源：

BIOMATERIALS | 1990年 / 11卷 / 09期

关键词：

amylase; biodegradation; Drug delivery; polysaccharide;

D O I：

10.1016/0142-9612(90)90029-P

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Starch polysaccharides were investigated as bioerodible matrices for enzymatically-controlled oral drug delivery. Corn starch was ionically cross-linked with calcium chloride. It was found that the cross-linked starch could be used for entrapment and controlled release of bioactive molecules. The release rate of large molecules was degradation-dependent due to amylase activity, which might target the release to the intestine, when the particles were taken orally. The release of small molecules such as salicyclic acid, was mainly by diffusion. © 1990.

引用

页码：695 / 698

页数：4

共 9 条

[1]

AMYLASES, ALPHA AND BETA [J].