RAT ALPHA-1-MICROGLOBULIN - COEXPRESSION IN LIVER WITH THE LIGHT CHAIN OF INTER-ALPHA-TRYPSIN INHIBITOR

被引：76

作者：

LINDQVIST, A

BRATT, T

ALTIERI, M

KASTERN, W

AKERSTROM, B

机构：

[1] UNIV LUND,DEPT MED & PHYSIOL CHEM,S-22101 LUND,SWEDEN

[2] HAGEDORN RES LAB,GENTOFTE,DENMARK

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 01期

基金：

英国医学研究理事会;

关键词：

ALPHA-1-MICROGLOBULIN; BIKUNIN; PRECURSOR PROTEIN; INTRACELLULAR CLEAVAGE; MESSENGER RNA; (RAT LIVER CDNA);

D O I：

10.1016/0167-4781(92)90462-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 1162 bp rat liver cDNA clone encoding the immunoregulatory plasma protein alpha(1)-microglobulin was isolated and sequenced. The open reading frame encoded a 349 amino acid polyprotein, including alpha(1)-microglobulin, 182 amino acids, and bikunin, the light chain of the plasma protein inter-alpha-trypsin inhibitor, 145 amino acids. The alpha(1)-microglobulin/bikunin mRNA was found only in the liver when different tissues were examined. Free alpha(1)-microglobulin and a polyprotein, containing both alpha(1)-microglobulin and inter-alpha-trypsin inhibitor epitopes, were found in the microsomal fraction from rat liver homogenates.

引用

页码：63 / 67

页数：5

共 33 条

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