THE METABOLISM OF 2,3,7,8-TETRABROMODIBENZODIOXIN IN THE RAT

被引：7

作者：

DEJONGH, J

BUSER, HR

POIGER, H

机构：

[1] SWISS FED RES STN,CH-8820 WADENSWIL,SWITZERLAND

[2] SWISS FED INST TECHNOL,INST TOXICOL,CH-8603 SCHWERZENBACH,SWITZERLAND

[3] UNIV ZURICH,CH-8603 SCHWERZENBACH,SWITZERLAND

来源：

XENOBIOTICA | 1993年 / 23卷 / 01期

关键词：

D O I：

10.3109/00498259309059358

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. 2,3,7,8-Tetrabromodibenzodioxin was administered to bile-duct-cannulated rats in a single oral dose. 2. The compound was metabolized in the liver and metabolites were secreted into the bile. 3. Several phenolic metabolites were identified as their methyl ether derivatives by gas chromatography-mass spectrometry after clean-up and methylation of bile samples. 4. The main metabolites were formed by aromatic hydroxylation and via displacement of Br-substituents (hydrolytic debromination). 5. Trace amounts of unmetabolized TBDD were also present in the bile.

引用

页码：19 / 26

页数：8

共 20 条

[1] PHARMACOKINETICS AND BIOLOGICAL-ACTIVITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN .1. DOSE-DEPENDENT TISSUE DISTRIBUTION AND INDUCTION OF HEPATIC ETHOXYRESORUFIN O-DEETHYLASE IN RATS FOLLOWING A SINGLE INJECTION [J].