DYNAMIC ORGANIZATION OF MOTOR CONTROL WITHIN THE OLIVOCEREBELLAR SYSTEM

被引:509
作者
WELSH, JP
LANG, EJ
SUGIHARA, I
LLINAS, R
机构
[1] Department of Physiology and Neuroscience, New York University Medical Center, New York, 10016
[2] Department of Physiology, Tokyo Medical and Dental University, School of Medicine, Bunkyo-ku, Tokyo, 113
关键词
D O I
10.1038/374453a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
WHAT is the role of the cerebellum in motor coordination? Such coordination depends upon the integrity of the inferior olive, a major cerebellar afferent, as its lesion produces ataxic and dysmetric movement abnormalities(1,2). Using multiple-microelectrode recordings, we report here that there are domains of Purkinje cell activity that are generated by olivary input during skilled tongue movements in rats, Such activity domains are highly rhythmic and time-locked to movement, Patterns of synchronous olivocerebellar activity are geometrically complex and can change during a sequence of movements. The results support the view that the inferior olive organizes movement in time, by entraining motor-neuronal firing through rhythmic activation of the cerebellum, and in space, by synchronously activating cell ensembles that allow the use of individual muscles. Dynamic repatterning of olivocerebellar synchrony may allow different combinations of muscles to be used for movements intended to have varying spatial structures.
引用
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页码:453 / 457
页数:5
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